The toy retailer will open its doors on Saturday 31st October at the Whitebirk retail park on the Blackburn/Hyndburn border.
Smyths has confirmed the opening will create more than 50 jobs, ranging from sales assistants to managers.
Spokesman Rob Guckian said: “Smyths Toys Superstores is delighted to announce the opening of a new store in Blackburn. We look forward to contributing to the area and offering the people here the best range and quality of products at the most competitive prices. With outstanding service and an amazing location, the new store is also sure to provide some fantastic employment opportunities to the local community.”