The channel will unveil the top 20 toys as voted by children at Kidtropolis.
ToysandMe, hosted and presented by YouTuber Tiana, has over 1.2 million subscribers and over one billion views gathered in just 15 months.
Exact details of the unveiling are being kept under wraps until the event.
Companies can enter the awards by going to www.ToyTesters.tv/Awards. Entries will close promptly at midnight on 15th August.
Gemma Gallagher, director at ToyTesters.tv, said: “We’re thrilled to be partnering with Toys andMe for the ToyTesters.tv Awards 2016 at Kidtropolis. It’s important to ToyTesters.tv that we stay true to our values of children voting for the best toys and games of the year. Partnering with ToysandMe is especially exciting as Tiana is such a huge, inspirational personality to children across the UK.”